PittsburghV1, Main, Exploration, bibRecord, 000B25

Trajectories of inflammatory markers and cognitive decline over 10 years

Identifieur interne : 000B25 ( Main/Exploration ); précédent : 000B24; suivant : 000B26

Trajectories of inflammatory markers and cognitive decline over 10 years

Auteurs : Andrea L. Metti [États-Unis] ; Kristine Yaffe [États-Unis] ; Robert M. Boudreau [États-Unis] ; Eleanor M. Simonsick [États-Unis] ; Ryan M. Carnahan [États-Unis] ; Suzanne Satterfield [États-Unis] ; Tamara B. Harris ; Hilsa N. Ayonayon [États-Unis] ; Caterina Rosano [États-Unis] ; Jane A. Cauley [États-Unis]

Source :

Neurobiology of aging [ 0197-4580 ] ; 2014.

RBID : PMC:4252870

Descripteurs français

KwdFr :
- Apolipoprotéine E4 (génétique), Cognition, Facteurs sexuels, Facteurs temps, Femelle, Génotype, Humains, Interleukine-6 (métabolisme), Marqueurs biologiques (métabolisme), Modèles de hasards proportionnels, Mâle, Médiateurs de l'inflammation (métabolisme), Protéine C-réactive (métabolisme), Risque, Sujet âgé, Troubles de la cognition (génétique), Troubles de la cognition (psychologie), Troubles de la cognition (étiologie), Études d'associations génétiques, Études prospectives.
MESH :
- génétique : Apolipoprotéine E4, Troubles de la cognition.
- métabolisme : Interleukine-6, Marqueurs biologiques, Médiateurs de l'inflammation, Protéine C-réactive.
- psychologie : Troubles de la cognition.
- étiologie : Troubles de la cognition.
- Cognition, Facteurs sexuels, Facteurs temps, Femelle, Génotype, Humains, Modèles de hasards proportionnels, Mâle, Risque, Sujet âgé, Études d'associations génétiques, Études prospectives.

English descriptors

KwdEn :
- Aged, Apolipoprotein E4 (genetics), Biomarkers (metabolism), C-Reactive Protein (metabolism), Cognition, Cognition Disorders (etiology), Cognition Disorders (genetics), Cognition Disorders (psychology), Female, Genetic Association Studies, Genotype, Humans, Inflammation Mediators (metabolism), Interleukin-6 (metabolism), Male, Proportional Hazards Models, Prospective Studies, Risk, Sex Factors, Time Factors.
MESH :
- chemical , genetics : Apolipoprotein E4.
- chemical , metabolism : Biomarkers, C-Reactive Protein, Inflammation Mediators, Interleukin-6.
- etiology : Cognition Disorders.
- genetics : Cognition Disorders.
- psychology : Cognition Disorders.
- Aged, Cognition, Female, Genetic Association Studies, Genotype, Humans, Male, Proportional Hazards Models, Prospective Studies, Risk, Sex Factors, Time Factors.

Abstract

We aimed to examine trajectories of inflammatory markers and cognitive decline over 10 years. Cox proportional hazards models were used to examine the association between interleukin-6 (IL-6) and C-reactive protein (CRP) trajectory components (slope, variability, and baseline level) and cognitive decline among 1,323 adults, age 70 to 79 years in the Health, Aging and Body Composition Study. We tested for interactions by sex and apolipoprotein E (APOE) genotype. In models adjusted for multiple covariates and comorbidities, extreme CRP variability was significantly associated with cognitive decline (HR 1.6, 95% CI: 1.1-2.3). This association was modified by sex and APOE e4 (p<0.001 for both), such that the association remained among women (HR=1.8; 95% CI: 1.1, 3.0) and among those with no APOE e4 allele (HR=1.6; 95% CI: 1.1, 2.5). There were no significant associations between slope or baseline level of CRP and cognitive decline, nor between IL-6 and cognitive decline. We believe CRP variability likely reflects poor control of or greater changes in vascular or metabolic disease over time, which in turn is associated with cognitive decline.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252870

DOI: 10.1016/j.neurobiolaging.2014.05.030
PubMed: 24997674
PubMed Central: 4252870

Affiliations:

États-Unis
Californie, Iowa, Maryland, Pennsylvanie, Tennessee

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Trajectories of inflammatory markers and cognitive decline over 10 years</title>
<author><name sortKey="Metti, Andrea L" sort="Metti, Andrea L" uniqKey="Metti A" first="Andrea L." last="Metti">Andrea L. Metti</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Yaffe, Kristine" sort="Yaffe, Kristine" uniqKey="Yaffe K" first="Kristine" last="Yaffe">Kristine Yaffe</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Psychiatry, University of California San Francisco, 185 Berry Street, Lobby 5, Ste. 5700, San Francisco, CA 94107</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Psychiatry, University of California San Francisco, 185 Berry Street, Lobby 5, Ste. 5700, San Francisco</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Neurology, University of California San Francisco, 185 Berry Street, Lobby 5, Ste. 5700, San Francisco, CA 94107</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of California San Francisco, 185 Berry Street, Lobby 5, Ste. 5700, San Francisco</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry Street, Lobby 5, Ste. 5700, San Francisco, CA 94107</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry Street, Lobby 5, Ste. 5700, San Francisco</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Boudreau, Robert M" sort="Boudreau, Robert M" uniqKey="Boudreau R" first="Robert M." last="Boudreau">Robert M. Boudreau</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Simonsick, Eleanor M" sort="Simonsick, Eleanor M" uniqKey="Simonsick E" first="Eleanor M." last="Simonsick">Eleanor M. Simonsick</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Clinical Research Branch, National Institute on Aging, 3001 S. Hanover Street, Baltimore, MD 21225</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Clinical Research Branch, National Institute on Aging, 3001 S. Hanover Street, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Carnahan, Ryan M" sort="Carnahan, Ryan M" uniqKey="Carnahan R" first="Ryan M." last="Carnahan">Ryan M. Carnahan</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Epidemiology, The University of Iowa College of Public Health, 105 River Street, Iowa City, IA 52242</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Iowa</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, The University of Iowa College of Public Health, 105 River Street, Iowa City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Satterfield, Suzanne" sort="Satterfield, Suzanne" uniqKey="Satterfield S" first="Suzanne" last="Satterfield">Suzanne Satterfield</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Department of Preventive Medicine, University of Tennessee at Memphis, 920 Madison Ave., Memphis, TN 38163</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Department of Preventive Medicine, University of Tennessee at Memphis, 920 Madison Ave., Memphis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name>
<affiliation><nlm:aff id="A8">Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, 7201 Wisconsin Ave., Bethesda, MD, 20892</nlm:aff>
<wicri:noCountry code="subfield">20892</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ayonayon, Hilsa N" sort="Ayonayon, Hilsa N" uniqKey="Ayonayon H" first="Hilsa N." last="Ayonayon">Hilsa N. Ayonayon</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry Street, Lobby 5, Ste. 5700, San Francisco, CA 94107</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry Street, Lobby 5, Ste. 5700, San Francisco</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rosano, Caterina" sort="Rosano, Caterina" uniqKey="Rosano C" first="Caterina" last="Rosano">Caterina Rosano</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cauley, Jane A" sort="Cauley, Jane A" uniqKey="Cauley J" first="Jane A." last="Cauley">Jane A. Cauley</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24997674</idno>
<idno type="pmc">4252870</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252870</idno>
<idno type="RBID">PMC:4252870</idno>
<idno type="doi">10.1016/j.neurobiolaging.2014.05.030</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">001474</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001474</idno>
<idno type="wicri:Area/Pmc/Curation">001449</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001449</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000202</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000202</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000C84</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C84</idno>
<idno type="wicri:Area/PubMed/Curation">000C84</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000C84</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000C84</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000C84</idno>
<idno type="wicri:Area/Ncbi/Merge">002889</idno>
<idno type="wicri:Area/Ncbi/Curation">002889</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002889</idno>
<idno type="wicri:doubleKey">0197-4580:2014:Metti A:trajectories:of:inflammatory</idno>
<idno type="wicri:Area/Main/Merge">000B36</idno>
<idno type="wicri:Area/Main/Curation">000B25</idno>
<idno type="wicri:Area/Main/Exploration">000B25</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Trajectories of inflammatory markers and cognitive decline over 10 years</title>
<author><name sortKey="Metti, Andrea L" sort="Metti, Andrea L" uniqKey="Metti A" first="Andrea L." last="Metti">Andrea L. Metti</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Yaffe, Kristine" sort="Yaffe, Kristine" uniqKey="Yaffe K" first="Kristine" last="Yaffe">Kristine Yaffe</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Psychiatry, University of California San Francisco, 185 Berry Street, Lobby 5, Ste. 5700, San Francisco, CA 94107</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Psychiatry, University of California San Francisco, 185 Berry Street, Lobby 5, Ste. 5700, San Francisco</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Neurology, University of California San Francisco, 185 Berry Street, Lobby 5, Ste. 5700, San Francisco, CA 94107</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of California San Francisco, 185 Berry Street, Lobby 5, Ste. 5700, San Francisco</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry Street, Lobby 5, Ste. 5700, San Francisco, CA 94107</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry Street, Lobby 5, Ste. 5700, San Francisco</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Boudreau, Robert M" sort="Boudreau, Robert M" uniqKey="Boudreau R" first="Robert M." last="Boudreau">Robert M. Boudreau</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Simonsick, Eleanor M" sort="Simonsick, Eleanor M" uniqKey="Simonsick E" first="Eleanor M." last="Simonsick">Eleanor M. Simonsick</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Clinical Research Branch, National Institute on Aging, 3001 S. Hanover Street, Baltimore, MD 21225</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Clinical Research Branch, National Institute on Aging, 3001 S. Hanover Street, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Carnahan, Ryan M" sort="Carnahan, Ryan M" uniqKey="Carnahan R" first="Ryan M." last="Carnahan">Ryan M. Carnahan</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Epidemiology, The University of Iowa College of Public Health, 105 River Street, Iowa City, IA 52242</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Iowa</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, The University of Iowa College of Public Health, 105 River Street, Iowa City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Satterfield, Suzanne" sort="Satterfield, Suzanne" uniqKey="Satterfield S" first="Suzanne" last="Satterfield">Suzanne Satterfield</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Department of Preventive Medicine, University of Tennessee at Memphis, 920 Madison Ave., Memphis, TN 38163</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Department of Preventive Medicine, University of Tennessee at Memphis, 920 Madison Ave., Memphis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name>
<affiliation><nlm:aff id="A8">Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, 7201 Wisconsin Ave., Bethesda, MD, 20892</nlm:aff>
<wicri:noCountry code="subfield">20892</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ayonayon, Hilsa N" sort="Ayonayon, Hilsa N" uniqKey="Ayonayon H" first="Hilsa N." last="Ayonayon">Hilsa N. Ayonayon</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry Street, Lobby 5, Ste. 5700, San Francisco, CA 94107</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry Street, Lobby 5, Ste. 5700, San Francisco</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rosano, Caterina" sort="Rosano, Caterina" uniqKey="Rosano C" first="Caterina" last="Rosano">Caterina Rosano</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cauley, Jane A" sort="Cauley, Jane A" uniqKey="Cauley J" first="Jane A." last="Cauley">Jane A. Cauley</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Neurobiology of aging</title>
<idno type="ISSN">0197-4580</idno>
<idno type="eISSN">1558-1497</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Apolipoprotein E4 (genetics)</term>
<term>Biomarkers (metabolism)</term>
<term>C-Reactive Protein (metabolism)</term>
<term>Cognition</term>
<term>Cognition Disorders (etiology)</term>
<term>Cognition Disorders (genetics)</term>
<term>Cognition Disorders (psychology)</term>
<term>Female</term>
<term>Genetic Association Studies</term>
<term>Genotype</term>
<term>Humans</term>
<term>Inflammation Mediators (metabolism)</term>
<term>Interleukin-6 (metabolism)</term>
<term>Male</term>
<term>Proportional Hazards Models</term>
<term>Prospective Studies</term>
<term>Risk</term>
<term>Sex Factors</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Apolipoprotéine E4 (génétique)</term>
<term>Cognition</term>
<term>Facteurs sexuels</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Interleukine-6 (métabolisme)</term>
<term>Marqueurs biologiques (métabolisme)</term>
<term>Modèles de hasards proportionnels</term>
<term>Mâle</term>
<term>Médiateurs de l'inflammation (métabolisme)</term>
<term>Protéine C-réactive (métabolisme)</term>
<term>Risque</term>
<term>Sujet âgé</term>
<term>Troubles de la cognition (génétique)</term>
<term>Troubles de la cognition (psychologie)</term>
<term>Troubles de la cognition (étiologie)</term>
<term>Études d'associations génétiques</term>
<term>Études prospectives</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Apolipoprotein E4</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biomarkers</term>
<term>C-Reactive Protein</term>
<term>Inflammation Mediators</term>
<term>Interleukin-6</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cognition Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Apolipoprotéine E4</term>
<term>Troubles de la cognition</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Interleukine-6</term>
<term>Marqueurs biologiques</term>
<term>Médiateurs de l'inflammation</term>
<term>Protéine C-réactive</term>
</keywords>
<keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Troubles de la cognition</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Cognition Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Troubles de la cognition</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Cognition</term>
<term>Female</term>
<term>Genetic Association Studies</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Proportional Hazards Models</term>
<term>Prospective Studies</term>
<term>Risk</term>
<term>Sex Factors</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Cognition</term>
<term>Facteurs sexuels</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Modèles de hasards proportionnels</term>
<term>Mâle</term>
<term>Risque</term>
<term>Sujet âgé</term>
<term>Études d'associations génétiques</term>
<term>Études prospectives</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">We aimed to examine trajectories of inflammatory markers and cognitive decline over 10 years. Cox proportional hazards models were used to examine the association between interleukin-6 (IL-6) and C-reactive protein (CRP) trajectory components (slope, variability, and baseline level) and cognitive decline among 1,323 adults, age 70 to 79 years in the Health, Aging and Body Composition Study. We tested for interactions by sex and apolipoprotein E (APOE) genotype. In models adjusted for multiple covariates and comorbidities, extreme CRP variability was significantly associated with cognitive decline (HR 1.6, 95% CI: 1.1-2.3). This association was modified by sex and APOE e4 (p<0.001 for both), such that the association remained among women (HR=1.8; 95% CI: 1.1, 3.0) and among those with no APOE e4 allele (HR=1.6; 95% CI: 1.1, 2.5). There were no significant associations between slope or baseline level of CRP and cognitive decline, nor between IL-6 and cognitive decline. We believe CRP variability likely reflects poor control of or greater changes in vascular or metabolic disease over time, which in turn is associated with cognitive decline.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Iowa</li>
<li>Maryland</li>
<li>Pennsylvanie</li>
<li>Tennessee</li>
</region>
</list>
<tree><noCountry><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name>
</noCountry>
<country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Metti, Andrea L" sort="Metti, Andrea L" uniqKey="Metti A" first="Andrea L." last="Metti">Andrea L. Metti</name>
</region>
<name sortKey="Ayonayon, Hilsa N" sort="Ayonayon, Hilsa N" uniqKey="Ayonayon H" first="Hilsa N." last="Ayonayon">Hilsa N. Ayonayon</name>
<name sortKey="Boudreau, Robert M" sort="Boudreau, Robert M" uniqKey="Boudreau R" first="Robert M." last="Boudreau">Robert M. Boudreau</name>
<name sortKey="Carnahan, Ryan M" sort="Carnahan, Ryan M" uniqKey="Carnahan R" first="Ryan M." last="Carnahan">Ryan M. Carnahan</name>
<name sortKey="Cauley, Jane A" sort="Cauley, Jane A" uniqKey="Cauley J" first="Jane A." last="Cauley">Jane A. Cauley</name>
<name sortKey="Rosano, Caterina" sort="Rosano, Caterina" uniqKey="Rosano C" first="Caterina" last="Rosano">Caterina Rosano</name>
<name sortKey="Satterfield, Suzanne" sort="Satterfield, Suzanne" uniqKey="Satterfield S" first="Suzanne" last="Satterfield">Suzanne Satterfield</name>
<name sortKey="Simonsick, Eleanor M" sort="Simonsick, Eleanor M" uniqKey="Simonsick E" first="Eleanor M." last="Simonsick">Eleanor M. Simonsick</name>
<name sortKey="Yaffe, Kristine" sort="Yaffe, Kristine" uniqKey="Yaffe K" first="Kristine" last="Yaffe">Kristine Yaffe</name>
<name sortKey="Yaffe, Kristine" sort="Yaffe, Kristine" uniqKey="Yaffe K" first="Kristine" last="Yaffe">Kristine Yaffe</name>
<name sortKey="Yaffe, Kristine" sort="Yaffe, Kristine" uniqKey="Yaffe K" first="Kristine" last="Yaffe">Kristine Yaffe</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B25 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000B25 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Amérique
   |area=    PittsburghV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4252870
   |texte=   Trajectories of inflammatory markers and cognitive decline over 10 years
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:24997674" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a PittsburghV1

This area was generated with Dilib version V0.6.38.
Data generation: Fri Jun 18 17:37:45 2021. Site generation: Fri Jun 18 18:15:47 2021

Serveur d'exploration sur Pittsburgh

Trajectories of inflammatory markers and cognitive decline over 10 years

Trajectories of inflammatory markers and cognitive decline over 10 years

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur Pittsburgh
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.